Vlasenko works regularly with many great artists such as Anna Netrebko, Yuri Bashmet, Vadim Repin, Denis Matsuev, Aida Garifullina, Nikolai Lugansky, Sergey Krylov, Maria Guleghina, Ludovic Tezier, Ildar Abdrazakov, Hibla Gerzmava, Dmitry Korchak, Lucas Debargue, Erwin Shrott, Joseph Calleja, Vittorio Grigolo, Alessandro Safina and many others. He has been in increasing demand all over Europe and Asia where engagements include the Tokyo Philharmonic Orchestra, Moscow and Saint-Petersburg Philharmonic Orchestras, European Symphony Orchestra (Gibraltar), the National Philharmonic orchestra of Russia, Russian National Orchestra, Orchestra del Teatro Comunale di Bologna, Orchestra I Pomeriggi Musicali di Milano, Latvian National Symphony Orchestra, Brussels Philharmonic, Latvian National Symphony, Tatarstan Symphony Orchestra, and Muenster Symphony.
Equally adept in the opera world he became the first Russian conductor to perform at the Rossini Opera Festival (Pesaro) with Il viaggio a Reims and L`inganno felice. Recent successes include concerts with Anna Netrebko and Yusif Eyvazov at Teatro Real (Madrid) and Gran Teatro del Liceu (Barcelona), Turandot at Teatro Petruzzelli (Bari), La traviata at Palacio de Bellas Artes (Mexico City), at Mikhailovsky Theatre (Saint-Petersburg), and at the Azerbaijan State Opera Theatre (Baku), Eugene Onegin at the Latvian National Opera (Riga), Le Comte Ory by Rossini in Tokyo, Lucia di Lammermoor at Teatro Calderón (Valladolid), Il barbiere di Siviglia at Kolobov Moscow Opera Theatre, Aida at the Khvorostovsky Opera Theatre (Krasnoyarsk), La fille du régiment by Donizetti at Elena Obraztsova Festival in the Great Hall of the Moscow Conservatory, and a gala concert at Bolshoi Theatre (Moscow).
He also recorded music for the Opening and Closing Ceremonies of the Winter Olympic Games in Sochi in 2014. In 2016/2017 he was a prinicpal conductor of the 4th season of the popular Russian TV show Great Opera on channel Kultura. From September 2018 Denis Vlasenko was invited to lead "Operatic and symphonic Conducting" course at the Popov Academy of Choral Art in Moscow. In 2021/2022 he conducted the great Russian tour of Anna Netrebko and Yusif Eyvazov. From January 2022, Denis Vlasenko was appointed to the position of Artistic Director and Chief Conductor of the State Academic Bolshoi Theatre of Uzbekistan named after Alisher Navoi in Tashkent.
